abstract：:Exposure to asbestos is the main cause of malignant pleural mesothelioma (MPM), a highly aggressive cancer of the pleura. Since the only tools for early detection are based on radiological tests, some authors focused on serum markers (i.e., mesothelin). The aim of this study was the evaluation of new serum biomarkers ...

journal_title：Disease markers

authors： Bonotti A,Foddis R,Landi S,Melaiu O,De Santi C,Giusti L,Donadio E,Ciregia F,Mazzoni MR,Lucacchini A,Bovenzi M,Comar M,Pantani E,Pistelli A,Cristaudo A

更新日期：2017-01-01 00:00:00

abstract：:The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (T...

journal_title：Disease markers

authors： Alajbeg IZ,Lapić I,Rogić D,Vuletić L,Andabak Rogulj A,Illeš D,Knezović Zlatarić D,Badel T,Vrbanović E,Alajbeg I

更新日期：2017-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/4703854.]. ...

journal_title：Disease markers

authors： Mutuiri SPM,Kutima HL,Mwapagha LM,Munyao JK,Kebira AN,Wanjiru I,Khamadi SA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Echocardiographic evaluation of left ventricular (LV) structural and functional alterations in hypertension has some limitations, potentially overcome by using biomarkers. ST2, a prognostic biomarker for heart failure and myocardial infarction patients, was less studied in hypertension. AIM:To analyze the r...

journal_title：Disease markers

authors： Farcaş AD,Anton FP,Goidescu CM,Gavrilă IL,Vida-Simiti LA,Stoia MA

更新日期：2017-01-01 00:00:00

abstract：:Prosthetic joint infection (PJI) is the most common cause of failure of total joint arthroplasty, but a gold standard for PJI diagnosis is still lacking. Advanced glycation end products (AGEs) are proinflammatory molecules inducing intracellular oxidative stress (OS) after binding to their cell membrane receptors (RAG...

journal_title：Disease markers

authors： Massaccesi L,Bonomelli B,Marazzi MG,Drago L,Romanelli MMC,Erba D,Papini N,Barassi A,Goi G,Galliera E

更新日期：2017-01-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is...

journal_title：Disease markers

authors： Jiang L,Chen F,Hu X,Hu Y,Wang Y,Zhang W,Peng Y,Cheng L

更新日期：2017-01-01 00:00:00

abstract：:Malignant mesothelioma (MM) is an aggressive malignancy of the serosal membranes. Early diagnosis and accurate prognostication remain problematic. BAP1 is a tumour suppressor gene commonly mutated in MM. Germline BAP1 mutation has been associated with early onset and less aggressive disease compared with sporadic MM. ...

journal_title：Disease markers

authors： Pulford E,Huilgol K,Moffat D,Henderson DW,Klebe S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes. METHODS:Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in p...

journal_title：Disease markers

authors： Trailin AV,Ostapenko TI,Nykonenko TN,Nesterenko SN,Nykonenko OS

更新日期：2017-01-01 00:00:00

abstract：Aims:The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians. Methods:Our population included 202 nonobese and 168 obese subjects. Anthropometric, biochemical, and microvascular parameters wer...

journal_title：Disease markers

authors： Boumiza S,Bchir S,Ben Nasr H,Abbassi A,Jacob MP,Norel X,Tabka Z,Chahed K

更新日期：2017-01-01 00:00:00

abstract：:Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients w...

journal_title：Disease markers

authors： Rao W,Zhou N,Zhang H,Liu R,Zhang S,Su Y,Yang G,Ma Y,Shi J,Yu Y,Yu Q

更新日期：2017-01-01 00:00:00

abstract：:Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca1...

journal_title：Disease markers

authors： Hogendorf P,Skulimowski A,Durczyński A,Kumor A,Poznańska G,Oleśna A,Rut J,Strzelczyk J

更新日期：2017-01-01 00:00:00

abstract：:Accumulating evidence suggests that the tumor microenvironment has a profound influence on tumor initiation and progression, opening a new avenue for studying tumor biology. Nonetheless, the prognostic values of the peritumoral expression of EpCAM and CD13 remain to be elucidated in hepatocellular carcinoma (HCC) pati...

journal_title：Disease markers

authors： Dai XM,Huang T,Yang SL,Zheng XM,Chen GG,Zhang T

更新日期：2017-01-01 00:00:00

abstract：:In this study, we aim to investigate the correlation between circulating tumor cells (CTCs) and the T lymphocyte subsets and NK cells in peripheral blood in non-small-cell lung cancer (NSCLC). The peripheral blood CTCs were determined by SET-iFISH. Flow cytometry was used to determine the distribution of T lymphocyte ...

journal_title：Disease markers

authors： Ye L,Zhang F,Li H,Yang L,Lv T,Gu W,Song Y

更新日期：2017-01-01 00:00:00

abstract：:Purpose. The aim of this study was to evaluate the sensitivity of pleural C-reactive protein (CRP) biomarker levels in identifying parapneumonic effusions. Methods. A single-center, retrospective review of 244 patients diagnosed with pleural effusions was initiated among patients at the Rabin Medical Center, Petah Tik...

journal_title：Disease markers

authors： Izhakian S,Wasser WG,Fox BD,Vainshelboim B,Kramer MR

更新日期：2016-01-01 00:00:00

abstract：:SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance of SIRT6 variants on...

journal_title：Disease markers

authors： Tang SS,Xu S,Cheng J,Cai MY,Chen L,Liang LL,Yang XL,Chen C,Liu XG,Xiong XD

更新日期：2016-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibili...

journal_title：Disease markers

authors： Barchitta M,Maugeri A

更新日期：2016-01-01 00:00:00

abstract：:We first investigated the difference in microRNA expression between normal NP cells and degenerative NP cells using gene chip. We have found that the expression of ERK1/2 was decreased with overexpression of miR-155 in normal nucleus pulposus cell. Expression of ERK1/2 was increased with inhibition of miR-155. Overexp...

journal_title：Disease markers

authors： Ye D,Dai L,Yao Y,Qin S,Xie H,Wang W,Liang W

更新日期：2016-01-01 00:00:00

abstract：:Decreased levels of brain-derived neurotrophic factor (BDNF) are assumed to play a crucial role in the pathophysiology of mild neurocognitive disorders (MNCDs). In this study, we compared plasma BDNF levels (at baseline and after two months of treatment with escitalopram) in patients with the main types of MNCDs and n...

journal_title：Disease markers

authors： Levada OA,Cherednichenko NV,Trailin AV,Troyan AS

更新日期：2016-01-01 00:00:00

abstract：:Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...

journal_title：Disease markers

authors： Dantas AT,Gonçalves SM,de Almeida AR,Gonçalves RS,Sampaio MC,Vilar KM,Pereira MC,Rêgo MJ,Pitta ID,Marques CD,Duarte AL,Pitta MG

更新日期：2016-01-01 00:00:00

abstract：:Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...

journal_title：Disease markers

authors： Yokoyama M,Watanabe T,Otaki Y,Takahashi H,Arimoto T,Shishido T,Miyamoto T,Konta T,Shibata Y,Daimon M,Ueno Y,Kato T,Kayama T,Kubota I

更新日期：2016-01-01 00:00:00

abstract：:Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...

journal_title：Disease markers

authors： Zhu J,Guo B,Fu M,Guo W,Yuan Y,Yuan H,Zhang S,Yu H

更新日期：2016-01-01 00:00:00

abstract：AIMS:To study the changes of the metabolic profile during the pathogenesis in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). METHODS:Forty male Sprague-Dawley (SD) rats were randomly divided into 5 groups (n = 8, each). PAH rats were induced by a single dose intraperitoneal injection of 60 mg/kg MC...

journal_title：Disease markers

authors： Lin T,Gu J,Huang C,Zheng S,Lin X,Xie L,Lin D

更新日期：2016-01-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic disorder and fibroblast growth factor 23 (FGF23) plays a key role in its pathogenesis. This study was conducted to describe a novel FGF23 detecting procedure and describe clinical features of the disease. Fourteen TIO cases were retrieved and FGF23 exp...

journal_title：Disease markers

authors： Hu F,Jiang C,Zhang Q,Shi H,Wei L,Wang Y

更新日期：2016-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments. Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making. Howeve...

journal_title：Disease markers

authors： Yin CQ,Yuan CH,Qu Z,Guan Q,Chen H,Wang FB

更新日期：2016-01-01 00:00:00

abstract：:Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...

journal_title：Disease markers

authors： Lupu M,Caruntu C,Ghita MA,Voiculescu V,Voiculescu S,Rosca AE,Caruntu A,Moraru L,Popa IM,Calenic B,Greabu M,Costea DE

更新日期：2016-01-01 00:00:00

abstract：:Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...

journal_title：Disease markers

authors： Mieczkowska J,Rutkowska E,Mosiewicz J,Mosiewicz B

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Increases in red blood cell distribution width (RDW) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) predict the mortality of chronic heart failure patients undergoing cardiac resynchronization therapy (CRT). It was hypothesized that RDW is independent of and possibly even superior to NT-proBNP fro...

journal_title：Disease markers

authors： Boros AM,Perge P,Jenei Z,Karády J,Zima E,Molnár L,Becker D,Gellér L,Prohászka Z,Merkely B,Széplaki G

更新日期：2016-01-01 00:00:00

abstract：:IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as s...

journal_title：Disease markers

authors： Neprasova M,Maixnerova D,Novak J,Reily C,Julian BA,Boron J,Novotny P,Suchanek M,Tesar V,Kacer P

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...

journal_title：Disease markers

authors： Hassan SH,El-Refai MI,Ghallab NA,Kasem RF,Shaker OG

更新日期：2015-01-01 00:00:00

abstract：AIM:The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. METHODS:From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were se...

journal_title：Disease markers

authors： Kincl V,Máchal J,Drozdová A,Panovský R,Vašků A

更新日期：2015-01-01 00:00:00

abstract：:Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. It is a multifactorial disease, and its development depends on infection by Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV), host genetic fact...

journal_title：Disease markers

authors： Sandoval-Bórquez A,Saavedra K,Carrasco-Avino G,Garcia-Bloj B,Fry J,Wichmann I,Corvalán AH

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA. Aims. To eval...

journal_title：Disease markers

authors： Fan Z,Pan J,Zhang Y,Wang Z,Zhu M,Yang B,Shi L,Jing H

更新日期：2015-01-01 00:00:00

abstract：:A limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma. However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and 4) has not been in...

journal_title：Disease markers

authors： Campillo JA,López-Hernández R,Martínez-Banaclocha H,Bolarín JM,Gimeno L,Mrowiec A,López M,Las Heras B,Minguela A,Moya-Quiles MR,Legáz I,Frías-Iniesta JF,García-Alonso AM,Álvarez-López MR,Martínez-Escribano JA,Muro M

更新日期：2015-01-01 00:00:00

abstract：:Several hemolytic markers are available to guide the differential diagnosis and to monitor treatment of hemolytic conditions. They include increased reticulocytes, an indicator of marrow compensatory response, elevated lactate dehydrogenase, a marker of intravascular hemolysis, reduced haptoglobin, and unconjugated hy...

journal_title：Disease markers

authors： Barcellini W,Fattizzo B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Impaired fasting glucose (IFG) through the nondiabetic range (100-125 mg/dL) is not considered in the cardiovascular (CV) risk profile. AIM:To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. MATERIAL AND METHODS:Cross-sectional study in 373...

journal_title：Disease markers

authors： Valentino G,Kramer V,Orellana L,Bustamante MJ,Casasbellas C,Adasme M,Salazar A,Navarrete C,Acevedo M

更新日期：2015-01-01 00:00:00

abstract：:Keloids are benign fibroproliferative tumors of the skin which commonly occur after injury mainly in darker skinned patients. Medical treatment is fraught with high recurrence rates mainly because of an incomplete understanding of the biological mechanisms that lead to keloids. The purpose of this project was to exami...

journal_title：Disease markers

authors： Jones LR,Young W,Divine G,Datta I,Chen KM,Ozog D,Worsham MJ

更新日期：2015-01-01 00:00:00

abstract：:GROβ (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little is known about GROβ expression in gastrointestinal stromal tumors (GIST) or the relationship between GROβ expression and clinical attributes of GIST. GROβ expression was examined via ...

journal_title：Disease markers

authors： Zhao H,Zhu H,Jin Q,Zhang S,Wang W,Wang D,Huang J

更新日期：2015-01-01 00:00:00

abstract：:Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant...

journal_title：Disease markers

authors： Abid K,Mili D,Kenani A

更新日期：2015-01-01 00:00:00

abstract：:Salivary oxidative stress markers represent a promising tool for monitoring of oral diseases. Saliva can often be contaminated by blood, especially in patients with periodontitis. The aim of our study was to examine the impact of blood contamination on the measurement of salivary oxidative stress markers. Saliva sampl...

journal_title：Disease markers

authors： Kamodyová N,Baňasová L,Janšáková K,Koborová I,Tóthová Ľ,Stanko P,Celec P

更新日期：2015-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a head and neck cancer that is highly found in distinct geographic areas, such as Southeast Asia. The management of NPC remains burdensome as the prognosis is poor due to the late presentation of the disease and the complex nature of NPC pathogenesis. Therefore, it is necessary to fin...

journal_title：Disease markers

authors： Janvilisri T

更新日期：2015-01-01 00:00:00